Edell E S, Cortese D A
Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn. 55905.
Chest. 1992 Nov;102(5):1319-22. doi: 10.1378/chest.102.5.1319.
Photodynamic therapy has been used since 1980 at our institution for the management of cancer of the tracheobronchial tree. We identified 13 patients (14 cancers) who were thought to be surgical candidates but who elected to have photodynamic therapy. Thirteen cancers (93 percent) had a complete response to hematoporphyrin-derivative phototherapy. Ten cancers (71 percent) showed a complete response after single treatment, and three (21 percent) required a second course of therapy to achieve a complete response. Ten (77 percent) of 13 cancers have shown no local recurrence. Three patients with persistent cancer underwent surgical resection and were found not to have nodal involvement. We concluded that photodynamic therapy is an alternative to surgical resection in the management of early superficial squamous cell carcinoma.
自1980年起，我院就开始使用光动力疗法治疗气管支气管树癌。我们确定了13例患者（14处癌症），他们原本被认为是手术候选者，但选择了接受光动力疗法。13处癌症（93%）对血卟啉衍生物光疗有完全反应。10处癌症（71%）单次治疗后即显示完全反应，3处（21%）需要第二个疗程的治疗才能达到完全反应。13处癌症中有10处（77%）未出现局部复发。3例持续存在癌症的患者接受了手术切除，结果发现并无淋巴结受累。我们得出结论，在早期浅表性鳞状细胞癌的治疗中，光动力疗法是手术切除的一种替代方法。
