Critchley E M, Vakil S D, Hayward H W, Owen V M
J Neurol Neurosurg Psychiatry. 1976 May;39(5):498-503. doi: 10.1136/jnnp.39.5.498.
In a study of chronic epileptics in a residential centre we recorded a 56% incidence of Dupuytren's disease. The lesions were usually bilateral and symmetrical and frequently associated with knuckle pads and plantar nodules. There was no direct relationship between Dupuytren's disease and frozen shoulder. Dupuytren's disease was seen equally in those with idiopathic or symptomatic epilepsy. The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone. Reasons are given for presuming that the association between Dupuytren's disease and antiepileptic therapy is mediated through the peripheral stimulation of tissue growth factors and not through the central release of growth hormone or through alterations in liver metabolism.
在一项针对居住中心慢性癫痫患者的研究中，我们记录到掌腱膜挛缩症的发病率为56%。病变通常为双侧对称，且常与指节垫和足底结节相关。掌腱膜挛缩症与肩周炎之间没有直接关系。在特发性或症状性癫痫患者中，掌腱膜挛缩症的发病率相同。发病率随癫痫病程的延长而增加，可能是长期服用苯巴比妥的后遗症。有理由推测，掌腱膜挛缩症与抗癫痫治疗之间的关联是通过组织生长因子的外周刺激介导的，而非通过生长激素的中枢释放或肝脏代谢的改变。
