Otová B, Sladká M, Votruba I, Holý A, Kren V
Department of Biology, 1st Faculty of Medicine, Charles University, Praha.
Folia Biol (Praha). 1993;39(3):136-41.
PMEA was administered i.p. daily on 10 consecutive days to inbred LEW rats inoculated with leukemic lymphoblastic cells KPH-Lw-I. The treatment was started 24 h after the inoculation. The observed cytostatic effects consisted in a significant prolongation of survival time associated with a suppression of the number of bone marrow leukemia cells with characteristic chromosomal marker of KPH-Lw-I leukemia as well as with a depression of the number of lymphoblasts in the blood.
连续10天每天经腹腔注射磷酸甲氧基乙基阿霉素（PMEA）给接种了白血病淋巴细胞KPH-Lw-I的近交系LEW大鼠。接种后24小时开始治疗。观察到的细胞抑制作用包括存活时间显著延长，伴有具有KPH-Lw-I白血病特征性染色体标记的骨髓白血病细胞数量减少以及血液中淋巴母细胞数量降低。
