Kremen J, Havlícek F, Pohlreich P
Neoplasma. 1980;27(2):197-202.
A spontaneous transplantable acute lymphatic leukemia in Lewis rats (KPH-Lw-I) is described. It is transplantable regardless of age and sex in inbred Lewis rats. The leukemic cells are of a normal karyotype. The progress of the disease is very rapid with many similarities to human acute lymphatic leukemia. Attempts to grow these leukemic cells in adult Wistar rats were unsuccessful, but they grow in newborn Wistar rats. During two years about eighty passages were done and the course of the disease was similar to that found in the original Lewis rat. No evidence for B-lymphocyte markers was found on the surface of leukemic cells.
本文描述了一种Lewis大鼠自发的可移植性急性淋巴细胞白血病（KPH-Lw-I）。在近交系Lewis大鼠中，无论年龄和性别，该白血病均可移植。白血病细胞具有正常核型。疾病进展非常迅速，与人类急性淋巴细胞白血病有许多相似之处。在成年Wistar大鼠中培养这些白血病细胞的尝试未成功，但它们可在新生Wistar大鼠中生长。在两年内进行了约80次传代，疾病进程与原始Lewis大鼠相似。在白血病细胞表面未发现B淋巴细胞标志物的证据。
