Schmidt D, Jung C E, Wolff G
Universitäts-Augenklinik, Freiburg, Germany.
Graefes Arch Clin Exp Ophthalmol. 1994 Feb;232(2):96-102. doi: 10.1007/BF00171670.
Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is known to occur in patients with familial adenomatous polyposis. Its relation to the course of the retinal blood vessels is emphasized in this publication. A 15-year-old girl with familial polyposis coli showed a longitudinal strip of whitish change following the course of a superior nasal artery of the left eye, falsely appearing to enclose the blood vessel like a sheath. A 34-year-old woman from another family with polyposis coli also showed a longitudinally orientated area of hypo- and hyperpigmentation close to temporal retinal veins. Two further patients revealed hyperpigmentation of the RPE under retinal vessels. It is hypothesized that these changes indicate an effect of the hypo- and hyperpigmentations of the RPE on the development of retinal vessels. In four patients, multiple dotlike hyperpigmentations were found in the extreme periphery of the retina; however, the bigger patchy hyperpigmentations were predominantly located in the midperiphery of the retina.
已知先天性视网膜色素上皮肥大（CHRPE）发生于家族性腺瘤性息肉病患者中。本出版物强调了其与视网膜血管行程的关系。一名患有家族性结肠息肉病的15岁女孩，左眼鼻上象限动脉行程处有一条纵向的白色改变带，看似像鞘一样包裹着血管。另一个患有结肠息肉病家族的34岁女性，在颞侧视网膜静脉附近也有一个纵向的色素减退和色素沉着区域。另外两名患者视网膜血管下方的视网膜色素上皮出现色素沉着。据推测，这些变化表明视网膜色素上皮的色素减退和色素沉着对视网膜血管发育有影响。在4名患者中，视网膜最周边发现多个点状色素沉着；然而，较大的斑片状色素沉着主要位于视网膜中周边。
