de Quadros C A, Carrasco P, Olivé J M
Int J Technol Assess Health Care. 1994 Winter;10(1):65-70. doi: 10.1017/s0266462300013994.
Although the vaccination initiatives undertaken during the past decade are the cornerstones for protecting the world's children and helping to ensure their survival and development, the vaccines currently being employed may become obstacles for further disease reduction or eradication. Their characteristics complicate or increase the burden on health care infrastructures to maintain or expand vaccine delivery systems. This paper examines an experience with the vaccine technologies that currently are being used by immunization programs in developing countries, illustrating the field problems and obstacles associated with their use. It discusses the advantages and benefits that would accrue if new or improved, heat-stable, multi-antigen vaccines that require only one or two, preferably oral, doses were to become available.
尽管过去十年开展的疫苗接种行动是保护全球儿童、助力确保其生存与发展的基石，但目前所使用的疫苗可能会成为进一步减少或根除疾病的障碍。其特性使维持或扩大疫苗接种系统的医疗保健基础设施变得复杂或负担加重。本文考察了发展中国家免疫规划目前所使用的疫苗技术的情况，阐述了与这些技术使用相关的实际问题和障碍。文中还讨论了如果能够获得新型或改良的、热稳定的、只需接种一或两剂（最好是口服）的多抗原疫苗可能带来的优势和益处。
