Langer S, Peters H, Schweizer K
Zentralbl Chir. 1978;103(15):991-6.
After comprehensive experimental especially morphological studies in animals, we started cryo-therapy of rectal carcinoma in 1972. We now present the first critical 5-years review concerning indication, clinical results and cryo-immunological features. In strongly indicated cases local tumour destruction by extremely low temperatures is superior to other palliative methods. Of 67 patients with rectal carcinoma treated with cryosurgery, 37 survived, 12 more than 36 months and 16 more than 24 months. Though there are only few hints indicating an increased immunological response following cryo-surgery, our investigations suggest a general influence on host's immunity by cryo-therapy.
在对动物进行了全面的实验尤其是形态学研究之后，我们于1972年开始了直肠癌的冷冻治疗。现在，我们给出了关于适应证、临床结果和冷冻免疫特征的首个关键的5年回顾。在明确适应证的病例中，极低温度导致的局部肿瘤破坏优于其他姑息治疗方法。在67例接受冷冻手术治疗的直肠癌患者中，37例存活，其中12例存活超过36个月，16例存活超过24个月。尽管仅有少数线索表明冷冻手术后免疫反应增强，但我们的研究提示冷冻治疗对宿主免疫有全面影响。
