Ito M, Enomoto H, Usa T, Villadolid M C, Ohtsuru A, Namba H, Sekine I, Yamashita S
Department of Pathology, Nagasaki University School of Medicine, Japan.
J Clin Pathol. 1993 Jul;46(7):682-3. doi: 10.1136/jcp.46.7.682.
The presence of parathyroid hormone related peptide (PTHrP) was studied in 20 patients with pituitary adenomas and one patient with pituitary adenocarcinoma. PTHrP expression was shown in almost all of the pituitary adenomas (95%) and in 100% (n = 7) growth hormone producing pituitary adenomas. A metastatic lesion from a pituitary growth hormone producing adenocarcinoma revealed strongly expressed PTHrP. It was weakly detected in normal pituitary cells in all of the specimens (n = 10). There was no significant correlation, however, between PTHrP expression and the clinical or pathological features of growth hormone producing tumours. Apart from an important role in the physiological function of the pituitary gland, PTHrP may be closely related to somatotroph tumorigenicity.
对20例垂体腺瘤患者和1例垂体腺癌患者进行了甲状旁腺激素相关肽（PTHrP）检测。几乎所有垂体腺瘤（95%）以及100%（n = 7）的垂体生长激素腺瘤均显示有PTHrP表达。一例垂体生长激素腺癌的转移灶显示PTHrP高表达。在所有标本（n = 10）的正常垂体细胞中仅微弱检测到PTHrP。然而，PTHrP表达与垂体生长激素腺瘤的临床或病理特征之间无显著相关性。除了在垂体生理功能中起重要作用外，PTHrP可能与生长激素细胞的致瘤性密切相关。
