Lie M A, van der Weijden G A, Timmerman M F, Abbas F, de Graaff J, Henskens Y M, van der Velden U
Department of Periodontology, Academic Centre for Dentistry, Amsterdam, The Netherlands.
J Clin Periodontol. 1994 Mar;21(3):171-6. doi: 10.1111/j.1600-051x.1994.tb00299.x.
To investigate a possible rôle for salivary blood-group antigens in the relative frequencies of selected periodontal pathogens and commensal oral micro-organisms, we studied the clinical and microbiological condition in young adults with or without blood group reactive substances in saliva (secretors or non-secretors respectively). Clinical measurements were recorded at the Ramfjord teeth in 81 1st-year dental students. In addition, presence of interproximal loss of attachment (LA) was assessed at sites with a pocket depth of > or = 4 mm. Microbiological samples were taken from one of the Ramfjord teeth (site without interproximal LA), from interproximal sites of > or = 4 mm in conjunction with LA, and from the saliva. The samples were analyzed for the presence of Actinomyces naeslundii, Actinomyces viscosus, Campylobacter rectus, Fusobacterium nucleatum, Peptostreptococcus micros, Prevotella intermedia, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Clinically, no statistically significant differences were found in the periodontal status between secretors (78% of our population) and non-secretors. Furthermore, the occurrence of the monitored micro-organisms was not correlated to the secretor status. It is concluded that bacterial colonization with the micro-organisms tested in this study, apparently occurred independent of secretor status. Among the periodontal pathogens, only P. intermedia was more frequently recovered from the saliva of subjects with interproximal LA (49%) than in those without (33%; p = 0.03). This finding was irrespective of the secretor status. Therefore, P. intermedia may be an important micro-organism in relation to the onset of periodontal destruction in young adults.
为了研究唾液血型抗原在特定牙周病原体和口腔共生微生物相对频率中可能发挥的作用，我们研究了唾液中存在或不存在血型反应物质的年轻成年人（分别为分泌型或非分泌型）的临床和微生物学状况。对81名一年级牙科学生的Ramfjord牙进行了临床测量。此外，在袋深≥4mm的部位评估邻面附着丧失（LA）的情况。微生物样本取自一颗Ramfjord牙（无邻面LA的部位）、伴有LA且袋深≥4mm的邻面部位以及唾液。分析样本中是否存在内氏放线菌、黏性放线菌、直肠弯曲菌、具核梭杆菌、微小消化链球菌、中间普氏菌、牙龈卟啉单胞菌和伴放线放线杆菌。临床上，分泌型（占研究人群的78%）和非分泌型之间的牙周状况未发现统计学上的显著差异。此外，所监测微生物的出现与分泌型状态无关。得出的结论是，本研究中所检测微生物的细菌定植显然与分泌型状态无关。在牙周病原体中，只有中间普氏菌在有邻面LA的受试者唾液中检出频率（49%）高于无邻面LA的受试者（33%；p = 0.03）。这一发现与分泌型状态无关。因此，中间普氏菌可能是与年轻成年人牙周破坏发病相关的一种重要微生物。
