Kast A, Peil H, Weisse I
Area of Non-Clinical Drug Safety, Boehringer Ingelheim GmbH, Ingelheim, Germany.
Lab Anim. 1994 Jan;28(1):80-9. doi: 10.1258/002367794781065834.
The occurrence of calcified foci at the junction of adrenal medulla and cortex in monkeys obtained from toxicity studies during a 10-year period is reported. The survey included reinvestigated adrenal samples from 274 male and 270 female rhesus monkeys and 52 male and 52 female cynomolgus monkeys. The incidence of calcified foci was 46% in male and 45% in female rhesus monkeys, and 6% in male cynomolgus monkeys, while their females did not show the lesion. In male rhesus monkeys, the mean number of foci was 4 for both glands, in females, 2 for the right and 4 for the left one. Initial stages indicated that the lesions develop possibly from focal apoptosis of medulla cells followed by a dystrophic mineralization. No correlation was observed concerning dose groups, test article, study length, testing facility, origin of monkeys, their sex, age, diet or final body weight. The foci of mineralization were dystrophic, species-specific in the rhesus monkey and possibly related to stress. The location of the foci at the cortico-medullary junction, precisely the location of the remnants of the fetal zone, may indicate their origin from this zone.
报告了在为期10年的毒性研究中获得的猴子肾上腺髓质与皮质交界处钙化灶的发生情况。该调查包括对274只雄性和270只雌性恒河猴以及52只雄性和52只雌性食蟹猴的肾上腺样本进行重新研究。钙化灶的发生率在雄性恒河猴中为46%，在雌性恒河猴中为45%，在雄性食蟹猴中为6%，而雌性食蟹猴未出现该病变。在雄性恒河猴中，两个肾上腺的病灶平均数为4个，在雌性中，右侧为2个，左侧为4个。初步阶段表明，病变可能由髓质细胞的局灶性凋亡继发营养不良性矿化发展而来。在剂量组、受试物、研究时长、测试机构、猴子来源、其性别、年龄、饮食或最终体重方面未观察到相关性。矿化灶是营养不良性的，在恒河猴中具有物种特异性，可能与应激有关。病灶位于皮质 - 髓质交界处，确切地说是胎儿区残余的位置，这可能表明它们起源于该区域。
