Moe J B, Ruch G L, Kenyon R H, Burek J D, Stookey J L
Vet Pathol. 1976;13(1):69-77. doi: 10.1177/030098587601300108.
Rhesus monkeys were inoculated intravenously or intraperitoneally with various numbers of Rickettsia rickettsii. Monkeys that were given more than 10(4) organisms intravenously died on days 3-6 after inoculation, whereas those given less than 10(3) intravenously or more than 10(4) intraperitoneally died on day 7 or later. There was no significant difference in incidence of lesions between the early- and late-death groups. Vasculitis and thrombosis occurred most frequently in the nares, pinna of the ear, scrotal skin, and testicle. Adrenal cortical necrosis was caused by capillary thrombosis. Rickettsiae, estimated by plaque formation in culture, were most numerous in the lung and spleen.
将不同数量的立氏立克次体静脉内或腹腔内接种给恒河猴。静脉内接种超过10⁴个病原体的猴子在接种后第3 - 6天死亡，而静脉内接种少于10³个或腹腔内接种超过10⁴个的猴子在第7天或更晚死亡。早期死亡组和晚期死亡组之间病变发生率没有显著差异。血管炎和血栓形成最常发生于鼻孔、耳廓、阴囊皮肤和睾丸。肾上腺皮质坏死是由毛细血管血栓形成所致。通过培养中的噬斑形成估算，立克次体在肺和脾中数量最多。
