Yanai T, Masegi T, Ueda K, Manabe J, Teranishi M, Takaoka M, Matsunuma N, Fukuda K, Goto N, Fujiwara K
Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
Vet Pathol. 1994 Sep;31(5):546-52. doi: 10.1177/030098589403100506.
Mineralization of various degrees was found in the brains of 79 (59%) of 134 cynomolgus monkeys (Macaca fascicularis). There was no age dependency in the incidence or severity, nor were there any abnormalities in growth, weight gain, or neurologic signs, although a slight sex difference was observed. The lesions, which were basophilic and intensely positive for periodic acid-Schiff or von Kossa stain, occurred in the vascular walls of the globus pallidus in two types: globoid bodies with prominent concentric lamellar structures in and around the arteriolar and venular wall (type A) and fine granules in the media of small or medium-sized arteries (type B). Electron microscopic examination revealed dense deposits in the degenerated media of small or medium-sized arteries or the thickened walls of the arterioles. X-ray microanalysis demonstrated the presence of calcium, phosphorus, iron, zinc, magnesium, and aluminum.
在134只食蟹猴（猕猴）的大脑中，79只（59%）发现了不同程度的矿化。矿化的发生率或严重程度与年龄无关，生长、体重增加或神经体征也无异常，不过观察到了轻微的性别差异。病变呈嗜碱性，高碘酸-希夫染色或冯·科萨染色呈强阳性，出现在苍白球的血管壁，有两种类型：球状体，在小动脉和小静脉壁及其周围有明显的同心层状结构（A型），以及中小动脉中膜内的细颗粒（B型）。电子显微镜检查显示，在中小动脉退化的中膜或小动脉增厚的壁中有致密沉积物。X射线微量分析表明存在钙、磷、铁、锌、镁和铝。
