铁角蕨属植物中天然及半合成二萜类化合物的抗菌活性

Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp.

作者信息

Rodríguez-Linde M E, Díaz R M, García-Granados A, Quevedo-Sarmiento J, Moreno E, Onorato M R, Parra A, Ramos-Cormenzana A

机构信息

Department of Microbiology, University of Granada, Spain.

出版信息

Microbios. 1994;77(310):7-13.

PMID:8159128

Abstract

The antimicrobial activity of 22 natural diterpenoids of endemic Sideritis from Eastern Andalusia (Spain) is described. Only ent-kaur-16-ene foliol and ent-beyer-15-ene isopusillatriol proved to be active towards Gram-positive and acid-fast bacteria. The introduction of a ketonic group at C-15 on ent-kaur-16-enic systems produced a remarkable degree of activity.

摘要

描述了来自西班牙安达卢西亚东部特有的铁角蕨属植物的22种天然二萜类化合物的抗菌活性。仅对映-贝壳杉-16-烯叶醇和对映-贝叶烷-15-烯异松果三醇对革兰氏阳性菌和抗酸菌具有活性。在对映-贝壳杉-16-烯体系的C-15位引入酮基产生了显著的活性程度。