来自鼠尾草根部的抗菌二萜类化合物。

Antibacterial diterpenes from the roots of Salvia viridis.

作者信息

Ulubelen A, Oksüz S, Kolak U, Bozok-Johansson C, Celik C, Voelter W

机构信息

University of Istanbul, Faculty of Pharmacy, Department of Chemistry, Turkey.

出版信息

Planta Med. 2000 Jun;66(5):458-62. doi: 10.1055/s-2000-8596.

DOI:10.1055/s-2000-8596

PMID:10909268

Abstract

Three new diterpenes, salviviridinol, viridinol, viridone, five known diterpenes, sugiol, 1-oxoferruginol, ferruginol, aethiopinone and microstegiol, abietane and rearranged abietane diterpenes were isolated from the roots of Salvia viridis. These compounds were assayed against S. aureus ATCC 6538 P, E. coli ATCC 8739, P. mirabilis ATCC 14153, K. pneumonia ATCC 4352, P. aeruginosa ATCC 27853, S. epidermidis ATCC 12228, E. faecalis ATCC 29212 and a yeast C. albicans ATCC 10231. 1-Oxoferruginol showed activity against B. subtilis, S. aureus, S. epidermidis and a modest activity against P. mirabilis, migrostegiol had a little activity against B. subtilis. The structures of the compounds were established by 1D and 2D NMR spectroscopic techniques.

摘要

从丹参的根部分离出三种新的二萜类化合物，即丹参绿醇、绿醇、绿酮，五种已知的二萜类化合物，即苏乔醇、1-氧代铁杉醇、铁杉醇、埃塞俄比亚酮和微穗草醇，以及枞酸型和重排枞酸型二萜类化合物。对这些化合物针对金黄色葡萄球菌ATCC 6538 P、大肠杆菌ATCC 8739、奇异变形杆菌ATCC 14153、肺炎克雷伯菌ATCC 4352、铜绿假单胞菌ATCC 27853、表皮葡萄球菌ATCC 12228、粪肠球菌ATCC 29212和白色念珠菌ATCC 10231进行了测定。1-氧代铁杉醇对枯草芽孢杆菌、金黄色葡萄球菌、表皮葡萄球菌显示出活性，对奇异变形杆菌有一定活性，微穗草醇对枯草芽孢杆菌有轻微活性。通过一维和二维核磁共振光谱技术确定了这些化合物的结构。