Bigham Andrea K, Munro Thomas A, Rizzacasa Mark A, Robins-Browne Roy M
Department of Microbiology and Immunology, School of Chemistry, The University of Melbourne, Victoria, 3010, Australia.
J Nat Prod. 2003 Sep;66(9):1242-4. doi: 10.1021/np030313i.
Three new neoclerodane diterpenoids, divinatorins A-C (7-9), have been isolated from the leaves of Salvia divinorum. The compounds were identified by spectroscopic methods as derivatives of the antibiotic (-)-hardwickiic acid (10), which was also isolated, along with four other known terpenoids. Neither the crude extract nor 7-9 displayed antimicrobial activity.
从鼠尾草叶中分离出了三种新的克罗烷二萜类化合物,占卜灵A - C(7 - 9)。通过光谱方法将这些化合物鉴定为抗生素(-)-哈德威克酸(10)的衍生物,该酸也与其他四种已知萜类化合物一起被分离出来。粗提取物和7 - 9均未表现出抗菌活性。