Oh S J, Kim D E, Kuruoglu H R
Department of Neurology, University of Alabama at Birmingham 35294.
Muscle Nerve. 1994 May;17(5):489-93. doi: 10.1002/mus.880170504.
In order to find the best diagnostic index of conduction block and abnormal temporal dispersion, the amplitude, duration, and area of the compound muscle action potentials (CMAP) were studied in 40 normal controls and 28 patients with acquired demyelinating neuropathies. In the normal subjects, there was a substantial difference among the various nerves in the degree of CMAP amplitude reduction and CMAP duration prolongation with proximal stimulation, and thus different criteria should be used for conduction block or abnormal temporal dispersion for a given nerve. In 28 patients with demyelinating neuropathy, 58 of 207 (28%) tested nerve segments showed nerve conduction velocity (NCV) evidence of demyelination. To identify "demyelination" in these segments, conduction block was best detected by the total area method in 71% of cases, and abnormal temporal dispersion was best by the negative-peak duration method. This study showed that the best diagnostic index for conduction block is the total area method and for abnormal temporal dispersion, the negative-peak duration method.
为了找到传导阻滞和异常时间离散的最佳诊断指标，对40名正常对照者和28例获得性脱髓鞘性神经病患者的复合肌肉动作电位（CMAP）的波幅、时限和面积进行了研究。在正常受试者中，不同神经在近端刺激时CMAP波幅降低程度和CMAP时限延长程度存在显著差异，因此对于给定神经，应采用不同的标准来诊断传导阻滞或异常时间离散。在28例脱髓鞘性神经病患者中，207个检测神经节段中有58个（28%）显示有脱髓鞘的神经传导速度（NCV）证据。为了识别这些节段中的“脱髓鞘”，71%的病例中通过总面积法能最好地检测到传导阻滞，而通过负峰时限法能最好地检测到异常时间离散。本研究表明，传导阻滞的最佳诊断指标是总面积法，异常时间离散的最佳诊断指标是负峰时限法。
