Selemon L D, Gottlieb J P, Goldman-Rakic P S
Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
Neuroscience. 1994 Jan;58(1):183-92. doi: 10.1016/0306-4522(94)90165-1.
Cytoarchitectonically defined cell-dense islands and regions of low acetylcholinesterase reactivity referred to as striosomes have been regarded as equivalent markers of the non-matrix compartment in the neostriatum. We examined islands and striosomes in adjacent sections to determine the degree of correspondence between the two neostriatal compartmental markers. Islands are aggregated centrally within the caudate, whereas striosomes are located throughout the entire nucleus, including the dorsolateral and ventromedial sectors. Moreover, even within the central sector, striosomes are more prevalent than islands. The present quantitative analysis suggests that islands may be further characterized as acetylcholinesterase-poor since the vast majority of islands co-localize with striosomes. However, due to the fact that striosomes are more numerous and more widely distributed throughout the neostriatum, less than a third of all striosomes are coincident with islands in adjacent sections. Comparison of each of these compartmental markers with the patterned terminal field of the prefrontal cortical projection revealed a near one-to-one correspondence between islands and terminal-free zones in the prefrontal projection. The percentage of striosomes which are aligned with fenestrations in the prefrontal projection is also quite high; however, because more striosomes than islands are found within the prefrontal terminal domain, some striosomes that fit within terminal-free zones do not have corresponding islands. These results indicate that islands and striosomes are not entirely equivalent compartmental markers and further suggest that contemporary, two-compartment models may not adequately represent the heterogeneity of the neostriatum.
细胞结构上定义的细胞密集岛以及低乙酰胆碱酯酶反应性区域（称为纹状体小体）被视为新纹状体中非基质区室的等效标志物。我们在相邻切片中检查了细胞密集岛和纹状体小体，以确定这两种新纹状体区室标志物之间的对应程度。细胞密集岛集中聚集在尾状核中央，而纹状体小体则遍布整个核，包括背外侧和腹内侧区域。此外，即使在中央区域，纹状体小体也比细胞密集岛更为普遍。目前的定量分析表明，细胞密集岛可能可进一步被描述为乙酰胆碱酯酶含量低，因为绝大多数细胞密集岛与纹状体小体共定位。然而，由于纹状体小体数量更多且在整个新纹状体中分布更广，在相邻切片中，所有纹状体小体中与细胞密集岛重合的不到三分之一。将这些区室标志物中的每一个与前额叶皮质投射的模式化终末场进行比较，发现细胞密集岛与前额叶投射中的无终末区之间几乎一一对应。与前额叶投射中的窗孔对齐的纹状体小体百分比也相当高；然而，由于在前额叶终末区域内发现的纹状体小体比细胞密集岛多，一些位于无终末区内的纹状体小体没有对应的细胞密集岛。这些结果表明，细胞密集岛和纹状体小体并非完全等效的区室标志物，进一步表明当代的两区室模型可能无法充分代表新纹状体的异质性。
