Hochfeld M, Druzin M L, Maia D, Wright J, Lambert R E, McGuire J
Department of Immunology and Rheumatology, Stanford University Medical School, California.
Obstet Gynecol. 1994 May;83(5 Pt 2):804-5.
Primary antiphospholipid antibody syndrome is a clinical entity that may threaten the health of both fetus and mother.
We report a fatal case of primary antiphospholipid antibody syndrome in a woman who developed catastrophic disease due to multisystem thrombosis in the postpartum period following a fetal death. Three years before her admission, primary antiphospholipid antibody syndrome was diagnosed on the basis of high titers of immunoglobulin G anticardiolipin antibody, a positive lupus anticoagulant, a false-positive VDRL, and fibrin deposits in the biopsy of a palmar lesion.
The physician must recognize the potentially catastrophic complications of pregnancy and the postpartum period in patients with antiphospholipid antibodies, and appropriate patient counseling should be provided.
原发性抗磷脂抗体综合征是一种可能威胁胎儿和母亲健康的临床病症。
我们报告一例原发性抗磷脂抗体综合征致死病例，该名女性在胎儿死亡后的产后期间因多系统血栓形成而发展为灾难性疾病。入院前三年，根据高滴度免疫球蛋白G抗心磷脂抗体、狼疮抗凝物阳性、性病研究实验室试验（VDRL）假阳性以及手掌病变活检中的纤维蛋白沉积，诊断为原发性抗磷脂抗体综合征。
医生必须认识到抗磷脂抗体患者在妊娠和产后期间可能出现的灾难性并发症，并应给予患者适当的咨询。
