利用牛DNA标记对绵羊（Ovis aries）中臀肌肥大基因进行染色体定位。
Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers.
作者信息
Cockett N E, Jackson S P, Shay T L, Nielsen D, Moore S S, Steele M R, Barendse W, Green R D, Georges M
机构信息
Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322-4815.
出版信息
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3019-23. doi: 10.1073/pnas.91.8.3019.
Abstract
A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries). Preliminary results indicate that an autosomal dominant gene may be responsible for this economically advantageous trait. We have exploited the conservation in sequence and chromosomal location of DNA markers across Bovidae to map the corresponding callipyge locus to ovine chromosome 18 using a battery of bovine chromosome 21 markers. Chromosomal localization of the ovine callipyge locus is the first step toward positional cloning of the corresponding gene.
摘要
最近在家养绵羊（Ovis aries）中发现了一种导致肌肉肥大并伴有消瘦和饲料效率提高的突变。初步结果表明，一个常染色体显性基因可能是造成这种具有经济优势性状的原因。我们利用牛科动物DNA标记在序列和染色体定位上的保守性，使用一系列牛21号染色体标记，将相应的臀肌肥大（callipyge）基因座定位到绵羊18号染色体上。绵羊臀肌肥大基因座的染色体定位是对相应基因进行定位克隆的第一步。
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