绵羊基因组的常染色体遗传连锁图谱。
An autosomal genetic linkage map of the sheep genome.
作者信息
Crawford A M, Dodds K G, Ede A J, Pierson C A, Montgomery G W, Garmonsway H G, Beattie A E, Davies K, Maddox J F, Kappes S W
机构信息
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
出版信息
Genetics. 1995 Jun;140(2):703-24. doi: 10.1093/genetics/140.2.703.
We report the first extensive ovine genetic linkage map covering 2070 cM of the sheep genome. The map was generated from the linkage analysis of 246 polymorphic markers, in nine three-generation full-sib pedigrees, which make up the AgResearch International Mapping Flock. We have exploited many markers from cattle so that valuable comparisons between these two ruminant linkage maps can be made. The markers, used in the segregation analyses, comprised 86 anonymous microsatellite markers derived from the sheep genome, 126 anonymous microsatellites from cattle, one from deer, and 33 polymorphic markers of various types associated with known genes. The maximum number of informative meioses within the mapping flock was 222. The average number of informative meioses per marker was 140 (range 18-209). Linkage groups have been assigned to all 26 sheep autosomes.
我们报道了首张覆盖绵羊基因组2070厘摩（cM）的全面绵羊遗传连锁图谱。该图谱是通过对246个多态性标记进行连锁分析生成的，这些标记来自九个三代全同胞家系，它们构成了AgResearch国际作图群体。我们利用了许多来自牛的标记，以便能够对这两张反刍动物连锁图谱进行有价值的比较。用于分离分析的标记包括86个源自绵羊基因组的匿名微卫星标记、126个来自牛的匿名微卫星标记、1个来自鹿的标记以及33个与已知基因相关的各种类型的多态性标记。作图群体中信息性减数分裂的最大数量为222。每个标记的信息性减数分裂平均数量为140（范围为18 - 209）。连锁群已被分配到所有26条绵羊常染色体上。
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