神经甾体的前体。
Precursors of the neurosteroids.
作者信息
Prasad V V, Vegesna S R, Welch M, Lieberman S
机构信息
Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, New York, NY 10019.
出版信息
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3220-3. doi: 10.1073/pnas.91.8.3220.
Abstract
In addition to the neurosteroids pregnenolone and dehydroepiandrosterone, organic solvent extracts of rat brains contain related compounds that react with various reagents to yield additional amounts of these ketosteroids. Among the chemicals producing these increments are triethylamine, HCl, FeCl3, and Pb(OAc)4. Most revealing is the action of FeSO4 on these extracts. This reducing agent also converts components of the extract into the two neurosteroids, suggesting the presence of sterol hydroperoxides or peroxides in brain. The clues provided by this study indicate that the chemical nature of the steroidal constituents existing in extracts of mammalian brains remains to be determined. It is likely that their association with neurological functions will be better understood when the structures of these substances are established.
摘要
除了神经甾体孕烯醇酮和脱氢表雄酮外，大鼠脑的有机溶剂提取物还含有相关化合物，这些化合物与各种试剂反应会产生额外量的这些酮甾体。产生这些增量的化学物质包括三乙胺、盐酸、氯化铁和醋酸铅（IV）。最具启发性的是硫酸亚铁对这些提取物的作用。这种还原剂还将提取物的成分转化为这两种神经甾体，表明大脑中存在甾醇氢过氧化物或过氧化物。这项研究提供的线索表明，哺乳动物脑提取物中存在的甾体成分的化学性质仍有待确定。当这些物质的结构确定后，它们与神经功能的关联可能会得到更好的理解。
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