Sany J, Morlock G, Clot J, Baldet P, Carcassonne Y, Serre H
Rev Rhum Mal Osteoartic. 1976 Jan;43(1):1-9.
The authors report a case of multiple kappa myeloma comboned with chronic lymphoid leukemia. The chronic lymphoid leukemia had evolved over a 13-year period in the classical manner, without serum or urnary monoclonal immunoglobulins. The multiple myeloma with blood and urinary kappa chains appeared suddenly with a typical clinical and radiological picture accompanied by renal insufficiency. Thd diagnosis was confirmed by the demonstration of both lymphocyte and plasmocyte cell proliferation and a study of the ultrastructure which showed the sarcomatous and secretory character of the plasmocytes. A study of plasmocyte subpopulation showed the proliferation of B lymphocytes. A combination of chronic lymphoid leukemia and multiple myeloma is exceptional. The physiopathological interpretation (mono or biclonal proliferation) is discussed in the light of current nosological conceptions concerning lymphoproliferative disorders.
作者报告了一例多发性κ型骨髓瘤合并慢性淋巴细胞白血病的病例。慢性淋巴细胞白血病以经典方式发展了13年，无血清或尿单克隆免疫球蛋白。伴有血液和尿κ链的多发性骨髓瘤突然出现，具有典型的临床和放射学表现，并伴有肾功能不全。通过淋巴细胞和浆细胞增殖的证实以及超微结构研究（显示浆细胞的肉瘤样和分泌特性）确诊。浆细胞亚群研究显示B淋巴细胞增殖。慢性淋巴细胞白血病和多发性骨髓瘤的合并情况较为罕见。根据当前关于淋巴增殖性疾病的疾病分类概念对病理生理学解释（单克隆或双克隆增殖）进行了讨论。
