Zalcberg J R, Cornell F N, Ireton H J, McGrath K M, McLachlan R, Woodruff R K, Wiley J S
Cancer. 1982 Aug 1;50(3):594-7. doi: 10.1002/1097-0142(19820801)50:3<594::aid-cncr2820500335>3.0.co;2-e.
A patient with multiple myeloma who subsequently developed chronic lymphocytic leukemia is reported. Initial studies demonstrated clinical and hematological features of multiple myeloma with an IgM lambda paraprotein. Skeletal disease was a significant presenting feature, although relapse occurred in extraosseous sites, particularly the pleura. He developed chronic lymphatic leukemia 31 months later and immunological studies showed the malignant lymphocytes to have kappa (Kappa) light chain surface immunoglobulin, demonstrating separate clonal origin of this patient's two B-cell malignancies.
报告了一例多发性骨髓瘤患者，该患者随后发展为慢性淋巴细胞白血病。初始研究显示多发性骨髓瘤的临床和血液学特征，伴有IgM λ副蛋白。骨骼疾病是一个显著的表现特征，尽管复发发生在骨外部位，尤其是胸膜。31个月后他发展为慢性淋巴细胞白血病，免疫学研究显示恶性淋巴细胞具有κ（kappa）轻链表面免疫球蛋白，表明该患者的两种B细胞恶性肿瘤起源不同。
