Mason D Y
Acta Haematol. 1976;55(1):1-9. doi: 10.1159/000207987.
A number of individuals in the population, including healthy blood donors and patients on methyldopa, show evidence erythrocyte coating by IgG autoantibodies (postive direct Coombs' test) without signs of a haemolytic state. The readiness with which red cells from these subjects are taken up by normal human monocytes in short term culture was examined, and compared with the phagocytosis of red cells from cases of IgG-mediated haemolytic anaemia. Red cells from non-haemolysing subjects were as avidly ingested in this system as were red cells from haemolysing patients. Similar results were obtained using normal red cells sensitised with antoantibody eluted from the cells of a healthy blood donor.
人群中的一些个体，包括健康献血者和服用甲基多巴的患者，显示出IgG自身抗体包被红细胞的证据（直接抗人球蛋白试验阳性），但没有溶血状态的迹象。研究了这些受试者的红细胞在短期培养中被正常人单核细胞摄取的容易程度，并与IgG介导的溶血性贫血病例的红细胞吞噬作用进行了比较。在这个系统中，非溶血受试者的红细胞与溶血患者的红细胞一样容易被摄取。使用从健康献血者细胞中洗脱的自身抗体致敏的正常红细胞也得到了类似的结果。
