Giovannini E
Acta Haematol. 1976;55(2):99-108. doi: 10.1159/000208001.
The author has studied the action of Cleland's reagent and Koshland's reagent on the erythropoietic factors present in the kidneys and the spleen of normal rabbits, in the plasma of bled rabbits and in the mixtures obtained through incubation of normal plasma with kidney and spleen homogenates. The results show that Cleland's reagent inhibits the activity of the renal and splenic erythro-stimulant factors, whereas it has no effect upon the erythropoietin in anaemic plasma and in plasma-kidney and plasma-spleen incubation mixtures. The activity of erythropoietin, on the other hand, is inhibited by Koshland's reagent, which has no influence on the renal and splenic erythro-stimulant factors.
作者研究了克莱兰试剂和科什兰试剂对正常家兔肾脏和脾脏中、放血家兔血浆中以及正常血浆与肾脏和脾脏匀浆孵育所得混合物中促红细胞生成因子的作用。结果表明，克莱兰试剂可抑制肾脏和脾脏促红细胞刺激因子的活性，而对贫血血浆以及血浆 - 肾脏和血浆 - 脾脏孵育混合物中的促红细胞生成素无影响。另一方面，促红细胞生成素的活性受到科什兰试剂的抑制，而该试剂对肾脏和脾脏促红细胞刺激因子无影响。
