Giovannini E, Bocchini V
Acta Haematol. 1975;53(2):75-81. doi: 10.1159/000208159.
The authors have studied the molecular weight of the erythropoietic factors present in the blood, in the kidney and in the spleen of the rabbit, by means of ultrafiltration experiments performed by using selective-permeability membranes. The erythropoietic factor present in the blood circulation shows a molecular weight of between 10,000 and 30,000. The factors detectable in the microsomal fraction of normal kidney, in the mitochondrial fraction of anaemic kidney and in the mitochondrial fraction of normal spleen show molecular weights of between 50,000 and 100,000. These data confirm the hypothesis already formulated regarding the renal origin of the splenic erythropoietic factor and the different nature of the renal erythropoietic factor compared with the plasmatic erythropoietin.
作者通过使用选择性渗透膜进行超滤实验，研究了兔血液、肾脏和脾脏中促红细胞生成因子的分子量。血液循环中存在的促红细胞生成因子分子量在10,000至30,000之间。在正常肾脏的微粒体部分、贫血肾脏的线粒体部分以及正常脾脏的线粒体部分中可检测到的因子分子量在50,000至100,000之间。这些数据证实了关于脾脏促红细胞生成因子的肾脏起源以及与血浆促红细胞生成素相比肾脏促红细胞生成因子性质不同的先前提出的假设。
