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The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network.TGN38糖蛋白包含两个不重叠的信号，这些信号介导其定位于反式高尔基体网络。
J Cell Biol. 1994 Apr;125(2):253-68. doi: 10.1083/jcb.125.2.253.
2
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.TGN38在反式高尔基体网络中的定位：一个含酪氨酸的胞质序列的作用
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3
The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex.当靶向早期高尔基体复合体时，v-sis癌蛋白会丧失转化活性。
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4
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TGN38 recycles basolaterally in polarized Madin-Darby canine kidney cells.TGN38在极化的犬肾Madin-Darby细胞中从基底外侧循环利用。
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本文引用的文献

1
Golgi retention signals: do membranes hold the key?高尔基体保留信号：膜是关键所在吗？
Trends Cell Biol. 1991 Dec;1(6):141-4. doi: 10.1016/0962-8924(91)90001-p.
2
TGN38/41: a molecule on the move.TGN38/41：一个处于动态变化的分子。
Trends Cell Biol. 1993 Aug;3(8):252-5. doi: 10.1016/0962-8924(93)90046-4.
3
TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain.TGN38通过其胞质结构域中含酪氨酸的基序维持在内质网反式高尔基体网络中。
EMBO J. 1993 May;12(5):2219-28. doi: 10.1002/j.1460-2075.1993.tb05870.x.
4
Retrieval of transmembrane proteins to the endoplasmic reticulum.跨膜蛋白向内质网的回收
J Cell Biol. 1993 Apr;121(2):317-33. doi: 10.1083/jcb.121.2.317.
5
TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.TGN38/41在细胞表面和反式高尔基体网络（TGN）之间循环：布雷菲德菌素A会影响其返回TGN的速率。
Mol Biol Cell. 1993 Jan;4(1):93-105. doi: 10.1091/mbc.4.1.93.
6
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.TGN38在反式高尔基体网络中的定位：一个含酪氨酸的胞质序列的作用
J Cell Biol. 1993 Mar;120(5):1123-35. doi: 10.1083/jcb.120.5.1123.
7
The differential degradation of two cytosolic proteins as a tool to monitor autophagy in hepatocytes by immunocytochemistry.通过免疫细胞化学方法，利用两种胞质蛋白的差异降解作为监测肝细胞自噬的一种工具。
J Cell Biol. 1993 Feb;120(4):897-908. doi: 10.1083/jcb.120.4.897.
8
Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region.从细胞外区域可溶性形式的流体动力学特性推断出的T细胞共受体CD8α的扩展结构证据。
J Biol Chem. 1993 Jan 25;268(3):2013-20.
9
Overlapping distribution of two glycosyltransferases in the Golgi apparatus of HeLa cells.两种糖基转移酶在HeLa细胞高尔基体中的重叠分布。
J Cell Biol. 1993 Jan;120(1):5-13. doi: 10.1083/jcb.120.1.5.
10
The first membrane spanning region of the lamin B receptor is sufficient for sorting to the inner nuclear membrane.核纤层蛋白B受体的第一个跨膜区域足以使其分选至内核膜。
J Cell Biol. 1993 Feb;120(3):631-7. doi: 10.1083/jcb.120.3.631.

TGN38糖蛋白包含两个不重叠的信号，这些信号介导其定位于反式高尔基体网络。

The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network.

作者信息

Ponnambalam S, Rabouille C, Luzio J P, Nilsson T, Warren G

机构信息

Cell Biology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.

出版信息

J Cell Biol. 1994 Apr;125(2):253-68. doi: 10.1083/jcb.125.2.253.

DOI:10.1083/jcb.125.2.253
PMID:8163544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2120028/
Abstract

The membrane-spanning and cytoplasmic domains of CD4 and CD8 were replaced by those of TGN38. After transient expression in HeLa cells, the location of the hybrid proteins was determined using immunofluorescence and quantitative immuno-electron microscopy, FACS analysis and metabolic labeling. The membrane-spanning domain was found to contain a signal that localized hybrid proteins to the TGN. This was in addition to the signal previously identified in the cytoplasmic domain (Bos, K., C. Wraight, and K. Stanley. 1993. EMBO (Eur. Mol. Biol. Organ) J. 12:2219-2228. Humphrey, J. S., P. J. Peters, L. C. Yuan, and J. S. Bonifacino. 1993. J. Cell Biol. 120:1123-1135. Wong, S. H., and W. Hong. 1993. J. Biol. Chem. 268:22853-22862). The different properties of these two signals suggest that each operates by a different mechanism.

摘要

CD4和CD8的跨膜结构域及胞质结构域被TGN38的相应结构域所取代。在HeLa细胞中瞬时表达后，利用免疫荧光、定量免疫电子显微镜、流式细胞术分析及代谢标记确定了杂交蛋白的定位。发现跨膜结构域含有一个将杂交蛋白定位到反式高尔基体网络（TGN）的信号。这是除了先前在胞质结构域中鉴定出的信号之外的信号（博斯，K.，C. 赖特，和K. 斯坦利。1993年。《欧洲分子生物学组织杂志》12:2219 - 2228。汉弗莱，J. S.，P. J. 彼得斯，L. C. 袁，和J. S. 博尼法西诺。1993年。《细胞生物学杂志》120:1123 - 1135。黄，S. H.，和W. 洪。1993年。《生物化学杂志》268:22853 - 228,62）。这两种信号的不同特性表明它们各自通过不同的机制发挥作用。