[人单克隆免疫球蛋白糖肽的制备与表征]

[Preparation and characterization of glycopeptides from human monoclonal immunoglobulin].

作者信息

Jouanneau J, Bourrillon R

出版信息

Biochimie. 1975;57(10):1203-8.

Abstract

The carbohydrate composition of an human IgM myeloma protein (IgM Du) has been determined. Seventeen homogeneous glycopeptides are described and exhibit a very large microheterogeneity. They appear as two different groups : the first one contains only mannose and N-acetyl glucosamine, while the other contains N-acetyl-glucosamine, mannose, galactose, fucose, and sialic acid in variable amounts. One glycopeptide termed IX1, which contains 6 mannose and 1 N-acetylglucosamine residues is located on the terminal portion of the Fc fragment and its aminoacid sequence has been determined : Tyr-Asx-Val-Ser.

摘要

已确定一种人IgM骨髓瘤蛋白（IgM Du）的碳水化合物组成。描述了17种均一的糖肽，它们表现出非常大的微观异质性。它们分为两个不同的组：第一组仅含有甘露糖和N-乙酰葡糖胺，而另一组含有不同量的N-乙酰葡糖胺、甘露糖、半乳糖、岩藻糖和唾液酸。一种名为IX1的糖肽，含有6个甘露糖和1个N-乙酰葡糖胺残基，位于Fc片段的末端部分，其氨基酸序列已确定：Tyr-Asx-Val-Ser。

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