人L型免疫球蛋白M（巨球蛋白）的寡糖单位。
The oligosaccharide units of a human type L immunoglobulin M (Macroglobulin).
作者信息
Johnson I, Clamp J R
出版信息
Biochem J. 1971 Aug;123(5):739-45. doi: 10.1042/bj1230739.
Abstract
- The carbohydrate composition of the monomeric unit of a type L macroglobulin (immunoglobulin M) was determined as 6 residues of fucose, 35 of mannose, 11 of galactose, 27 of N-acetylglucosamine and 9 of sialic acid. 2. Two types of oligosaccharide unit were present in the protein, one of which (Ca type) contained fucose, mannose, galactose, N-acetylglucosamine and sialic acid in the molar proportions 1:3-4:2:3-5:0-2, and the other (Cb type) contained mannose and N-acetylglucosamine in the proportions 6-8:2-3. 3. A tentative structure is proposed for the Cb type unit. 4. An S-carboxymethylcysteine-containing glycopeptide with a Ca-type unit was isolated after reduction, alkylation and tryptic digestion of the protein. 5. The immunoglobulin monomer appears to contain six oligosaccharide units of the Ca type and two of the Cb type.
摘要
- 已确定L型巨球蛋白（免疫球蛋白M）单体单元的碳水化合物组成，其中岩藻糖6个残基、甘露糖35个残基、半乳糖11个残基、N-乙酰葡糖胺27个残基、唾液酸9个残基。2. 该蛋白质中存在两种类型的寡糖单元，其中一种（Ca型）所含岩藻糖、甘露糖、半乳糖、N-乙酰葡糖胺和唾液酸的摩尔比例为1:3 - 4:2:3 - 5:0 - 2，另一种（Cb型）所含甘露糖和N-乙酰葡糖胺的比例为6 - 8:2 - 3。3. 提出了Cb型单元的初步结构。4. 对该蛋白质进行还原、烷基化和胰蛋白酶消化后，分离出一种含有Ca型单元的含S-羧甲基半胱氨酸的糖肽。5. 免疫球蛋白单体似乎含有6个Ca型寡糖单元和2个Cb型寡糖单元。
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