淋球菌核糖体作为皮肤试验抗原。I. 敏感性和特异性的初步试验。
Gonococcal ribosomes as skin test antigens. I. Preliminary tests of sensitivity and specificity.
作者信息
Koostra W L, Judd R C, Baker R E
出版信息
Br J Vener Dis. 1976 Feb;52(1):24-7. doi: 10.1136/sti.52.1.24.
Ribosomes isolated from N. gonorrhoeae and N. meningitidis were used as skin test antigens in guinea-pigs which had been previously sensitized with killed Neisseria cells in incomplete Freund adjuvant. Intradermal injection of ribosomes from skin test dose N. gonorrhoeae into the skin of animals sensitized to the homologous organism was characterized by a specificity based upon ribosomal skin test dose 50's (STD50) sensitivity which was at least five-fold greater than that of the animals sensitized to the heterologous organism. The sensitized guinea-pigs had lost their skin-test reactivity within 3 months of the cessation of immunization but regained it immediately on reimmunization. The results of this model system indicate that gonococcal ribosomes may be used as antigens in skin testing or other testing modes in gonorrhoea.
从淋病奈瑟菌和脑膜炎奈瑟菌中分离出的核糖体被用作豚鼠皮肤试验抗原，这些豚鼠先前已在不完全弗氏佐剂中用灭活的奈瑟菌细胞致敏。将来自淋病奈瑟菌皮肤试验剂量的核糖体皮内注射到对同源生物体致敏的动物皮肤中，其特征是基于核糖体皮肤试验剂量50（STD50）敏感性的特异性，该敏感性比对异源生物体致敏的动物至少高五倍。致敏的豚鼠在免疫停止后3个月内失去了皮肤试验反应性，但在再次免疫后立即恢复。该模型系统的结果表明，淋球菌核糖体可用作淋病皮肤试验或其他检测方式的抗原。
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