Kingsmore S F, Silva O E, Hall B D, Sheldon E A, Cripe L D, St Clair E W
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
J Rheumatol. 1993 Sep;20(9):1588-91.
Multicentric Castleman's disease (MCD), or multicentric angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder which typically present with constitutional symptoms, multicentric lymphadenopathy, hepatosplenomegaly, effusions, and ascites. We describe a patient with several novel manifestations of MCD: sicca syndrome, lacrimal and salivary gland enlargement, cardiomyopathy, and palmar and plantar rash. Treatment of MCD with chlorambucil and prednisone was effective in the short term followup of this patient. MCD merits consideration in patients with lymphadenopathy and multisystem disease, including sicca syndrome, heart failure or rash.
多中心性Castleman病（MCD），即多中心性血管滤泡性淋巴结增生，是一种罕见的淋巴增殖性疾病，通常表现为全身症状、多中心淋巴结病、肝脾肿大、积液和腹水。我们描述了一名患有MCD多种新表现的患者：干燥综合征、泪腺和唾液腺肿大、心肌病以及手掌和足底皮疹。在该患者的短期随访中，用苯丁酸氮芥和泼尼松治疗MCD有效。对于患有淋巴结病和多系统疾病（包括干燥综合征、心力衰竭或皮疹）的患者，应考虑MCD。
