Potter L S, Dalberth B T, Cañamar R, Betz M
Office of Population Research, Princeton University, NJ 08544, USA.
Contraception. 1997 Nov;56(5):305-12. doi: 10.1016/s0010-7824(97)00160-1.
This article examines the characteristics of the first group of depot medroxyprogesterone acetate (DMPA) acceptors after US Food and Drug Administration (FDA) approval of the method and evaluates their continuation rates and factors associated with discontinuation. This was a population based retrospective study based on 12 months of clinic data for 510 women who began using DMPA in 1993 at a large county health department. Cumulative 12 month life table rates were calculated for the entire group and were then stratified by selected characteristics. The 4, 8, and 12 month continuation rates were 67%, 46%, and 35%, respectively. More than half of these women discontinued because of bleeding and nonbleeding side effects (25% and 28%, respectively). Almost 20% of these women were considered discontinuers because they waited longer than 16 weeks to return for an injection. As measured in this study, continuation rates for this first group of DMPA acceptors were low. The next step is to determine if the characteristics and patterns of use of these "pioneer" acceptors are representative of more recent acceptors, and if lessons learned from this group will lead to higher continuation rates.
本文研究了美国食品药品监督管理局（FDA）批准醋酸甲羟孕酮长效避孕针（DMPA）使用方法后首批使用者的特征，并评估了其续用率及与停用相关的因素。这是一项基于人群的回顾性研究，数据来源于1993年在某大型县卫生部门开始使用DMPA的510名女性的12个月临床资料。计算了整个群体的12个月累积生命表率，然后按选定特征进行分层。4个月、8个月和12个月的续用率分别为67%、46%和35%。这些女性中超过一半因出血和非出血性副作用而停用（分别为25%和28%）。近20%的女性被视为停用者，因为她们等待超过16周才回来注射。根据本研究的测量，首批DMPA使用者的续用率较低。下一步是确定这些“先驱”使用者的特征和使用模式是否代表了近期使用者，以及从该群体吸取的经验教训是否会带来更高的续用率。
