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[一名患有获得性γ球蛋白异常血症、慢性腹泻和细菌过度生长综合征患者的肠道淋巴样结节增生]

[Intestinal lymphoid nodular hyperplasia in a patient with acquired dysgammaglobulinemia, chronic diarrhea, and bacterial overgrowth syndrome].

作者信息

Castañeda-Romero B, Díaz-Caldelas L, Galván-Guerra E, Sixtos S, Arista J, Uscanga L

机构信息

Departamento de Gastroenterología, Instituto Nacional de la Nutrición Salvador Zubirán, México, DF.

出版信息

Rev Gastroenterol Mex. 1993 Jul-Sep;58(3):225-8.

PMID:8165401
Abstract

The association between intestinal nodular lymphoid hyperplasia (INLH) and acquired dysgammaglobulinemia was first described by Hermans et al in 1966. One of the largest series reported in the literature is mexican. We described the clinical out come of a young man with diarrhea, steatorrhea and history of upper respiratory tract infections in whom INLH was established by clinical, radiological, endoscopic and histopathologic studies. Jejunal fluid showed infection by E. coli, C. freundii and Candida albicans as well as cysts of Giardia lamblia. Serum concentration of Ig A and Ig M were decreased. As well as B lymphocytes count in peripheral blood. The patient received treatment with itraconazole, ciprofloxacin and furazolidone with an excellent response. At present he is asymptomatic with cyclic doses of antibiotics and parenteral administration of gammaglobulins.

摘要

肠道结节性淋巴组织增生(INLH)与获得性丙种球蛋白异常血症之间的关联最早由赫尔曼斯等人于1966年描述。文献报道的最大系列之一来自墨西哥。我们描述了一名患有腹泻、脂肪泻及上呼吸道感染病史的年轻男性的临床结局,通过临床、放射学、内镜及组织病理学研究确诊为INLH。空肠液显示有大肠杆菌、弗氏柠檬酸杆菌和白色念珠菌感染,以及蓝氏贾第鞭毛虫囊肿。血清IgA和IgM浓度降低,外周血B淋巴细胞计数也降低。该患者接受了伊曲康唑、环丙沙星和呋喃唑酮治疗,反应良好。目前,他在周期性使用抗生素及胃肠外给予丙种球蛋白的情况下无症状。

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