一组成人结节性淋巴组织增生的临床特征：单中心经验
Clinical characteristics of a group of adults with nodular lymphoid hyperplasia: a single center experience.
作者信息
Rubio-Tapia Alberto, Hernández-Calleros Jorge, Trinidad-Hernández Sagrario, Uscanga Luis
机构信息
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Tlalpan 14000, Distrito Federal, Mexico.
出版信息
World J Gastroenterol. 2006 Mar 28;12(12):1945-8. doi: 10.3748/wjg.v12.i12.1945.
AIM
To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia (NLH).
METHODS
Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical records.
RESULTS
Small-bowel NLH was diagnosed in 18 cases. The female: male ratio was 2:1. The most frequent symptoms were diarrhea (72%), involuntary weight loss (72%) and abdominal pain (61%). Nine patients (50%) had immunodeficiency. Small-bowel bacterial overgrowth was found in three (17%) cases. At small-bowel NLH diagnosis, three (17%) had associated lymphoma: two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established. Giardia lamblia infection was found in only one patient with hypogammaglobulinemia (Herman's syndrome).
CONCLUSIONS
NLH is uncommon in adult patients. Associated diseases are immunodeficiency and lymphoid tissue malignancies.
目的
描述一组患有小肠结节性淋巴组织增生（NLH）的成人患者的临床和组织学特征。
方法
在我们机构的病理记录中对患者进行了为期五年的搜索。使用严格的组织病理学标准对活检材料进行重新评估。临床数据来自病历。
结果
诊断出18例小肠NLH。男女比例为2:1。最常见的症状是腹泻（72%）、非自愿体重减轻（72%）和腹痛（61%）。9例患者（50%）有免疫缺陷。3例（17%）发现小肠细菌过度生长。在小肠NLH诊断时，3例（17%）伴有淋巴瘤：2例肠道淋巴瘤和1例肠外淋巴瘤。在2例伴有绒毛萎缩和抗肌内膜抗体的患者中确诊为乳糜泻。仅在1例患有低丙种球蛋白血症（赫尔曼综合征）的患者中发现了贾第虫感染。
结论
NLH在成年患者中并不常见。相关疾病是免疫缺陷和淋巴组织恶性肿瘤。
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