儿童血液系统恶性肿瘤中的血清可溶性白细胞介素-2受体和肿瘤坏死因子-α

Serum soluble interleukin-2 receptors and tumor necrosis factor-alpha in hematological malignancies of childhood.

作者信息

Cetingül N, Yener E, Oztop S, Nişli G

机构信息

Department of Pediatric Oncology, Medical Faculty, Ege University, Izmir, Turkey.

出版信息

Acta Paediatr Jpn. 1994 Feb;36(1):49-52. doi: 10.1111/j.1442-200x.1994.tb03128.x.

DOI:10.1111/j.1442-200x.1994.tb03128.x

PMID:8165908

Abstract

The levels of soluble interleukin-2 receptors (sIL-2R) and tumor necrosis factor (TNF) were determined in the serum of 61 children with hematological malignancy, including 20 patients with leukemia and 16 with lymphoma in active state of malignancy, and 20 patients with leukemia and 5 with lymphoma in complete remission. In addition, serum samples from 15 healthy children were used as controls. It was found that the mean serum levels of sIL-2R and TNF were significantly increased in active malignancy (207.0 +/- 17.1 pmol/L for sIL-2R; 209.7 +/- 35.0 pg/mL for TNF) compared to the remission status and normal controls (P < 0.001). No such difference was observed between leukemia and lymphoma groups. It was concluded that serum sIL-2R and TNF are of potential value in the diagnosis and follow up of patients with neoplastic diseases.

摘要

测定了61例血液系统恶性肿瘤患儿血清中可溶性白细胞介素-2受体（sIL-2R）和肿瘤坏死因子（TNF）的水平，其中包括20例处于恶性活动期的白血病患者、16例处于恶性活动期的淋巴瘤患者、20例完全缓解期的白血病患者和5例完全缓解期的淋巴瘤患者。此外，选取15例健康儿童的血清样本作为对照。结果发现，与缓解期患者及正常对照组相比，恶性活动期患者血清中sIL-2R和TNF的平均水平显著升高（sIL-2R为207.0±17.1 pmol/L；TNF为209.7±35.0 pg/mL）（P<0.001）。白血病组和淋巴瘤组之间未观察到此类差异。得出结论，血清sIL-2R和TNF在肿瘤性疾病患者的诊断和随访中具有潜在价值。