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战争应激对血小板苯二氮䓬受体的影响。

Alteration of platelet benzodiazepine receptors by stress of war.

作者信息

Weizman R, Laor N, Karp L, Dagan E, Reiss A, Dar D E, Wolmer L, Gavish M

机构信息

Tel Aviv Community Mental Health Center, Israel.

出版信息

Am J Psychiatry. 1994 May;151(5):766-7. doi: 10.1176/ajp.151.5.766.

DOI:10.1176/ajp.151.5.766
PMID:8166322
Abstract

Mitochondrial benzodiazepine receptors play a major role in steroidogenesis. The authors determined plasma cortisol levels, platelet levels of mitochondrial benzodiazepine receptors, and anxiety and depression scores in 11 civilians exposed to the Persian Gulf war. The density of mitochondrial benzodiazepine receptors was 22% and 15% lower before and during the war, respectively, than 4 weeks after the end of the war. Relief of stress led to an increase in receptors, which correlated with the improvement in anxiety but not mood.

摘要

线粒体苯二氮䓬受体在类固醇生成中起主要作用。作者测定了11名曾暴露于海湾战争的平民的血浆皮质醇水平、血小板线粒体苯二氮䓬受体水平以及焦虑和抑郁评分。战前和战时线粒体苯二氮䓬受体的密度分别比战争结束4周后低22%和15%。压力缓解导致受体增加,这与焦虑的改善相关,但与情绪改善无关。

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