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[微波对依他尼酸耳毒性所致听力损失治疗价值的实验研究]

[Experimental study on the therapeutic value of microwave on hearing loss due to ethacrynic acid ototoxicity].

作者信息

Chen X M

机构信息

Renji Hospital, Shanghai Sencond Medical University.

出版信息

Zhonghua Er Bi Yan Hou Ke Za Zhi. 1993;28(4):225-7, 252.

PMID:8167043
Abstract

Ischemia of the stria vascularis in the cochlea associated with temporal hearing loss was found in guinea pigs with intravenous othacrynic acid injection. Using this animal model, we studied the therapeutic value of low power density microwave on the ischemic stria vascularis. Experimental findings confirmed that microwave irradiation on the ear might prompt a quicker recovery of hearing. Meanwhile, milder pathological changes of the stria vascularis were shown either on light microscopy or on TEM in the microwave treated animals. Hence, it is suggested that microwave irradiation causes an improvement of microcirculation and an alleviation of lesions in the stria vascularis. The study has provided an experimental basis of microwave treatment for the hearing impairment due to microcirculation disorder in the inner ear.

摘要

静脉注射速尿的豚鼠出现了与颞部听力损失相关的耳蜗血管纹缺血。利用该动物模型,我们研究了低功率密度微波对缺血性血管纹的治疗价值。实验结果证实,耳部微波照射可能促使听力更快恢复。同时,在接受微波治疗的动物中,光镜或透射电镜下显示血管纹的病理变化较轻。因此,提示微波照射可改善微循环并减轻血管纹的病变。该研究为微波治疗内耳微循环障碍所致听力损害提供了实验依据。

相似文献

1
[Experimental study on the therapeutic value of microwave on hearing loss due to ethacrynic acid ototoxicity].[微波对依他尼酸耳毒性所致听力损失治疗价值的实验研究]
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1993;28(4):225-7, 252.
2
[Deafness, induced by sodium ethacrynate in guinea pigs, alleviated by microwave treatment].[豚鼠乙氧苯唑酸致聋后经微波治疗缓解]
Rev Laryngol Otol Rhinol (Bord). 1992;113(2):133-5.
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Laryngoscope. 1991 Jul;101(7 Pt 1):709-16. doi: 10.1288/00005537-199107000-00004.
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Cisplatin ototoxicity in guinea pigs with special reference to toxic effects in the stria vascularis.顺铂对豚鼠的耳毒性,特别提及对血管纹的毒性作用。
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