Forlini A, Gentileschi P, Germani P P, Paganelli C, Russo F, Nasrollah N
Cattedra di Semeiotica Chirurgica, Università degli Studi Tor Vergata, Roma.
G Chir. 1993 Dec;14(9):504-9.
The natural history of liver cirrhosis shows one third of patients bleeding from esophageal varices. The first episode of bleeding has a 40% mortality rate and 70% of survivors will have another haemorrhage within a year. To overcome this dramatic sequence the following types of prophylactic treatment have been attempted: portocaval shunt, B-blockers, endoscopic sclerotherapy. Medical Literature shows no proven benefits from these procedures. Endoscopic sclerotherapy seems to have the best results. Thus, to be more successful we suggest a better selection of patients to undergo prophylactic sclerotherapy, also improving the prognostic criteria which could predict the bleeding. Esophagoscopy makes it possible to examine some of the predictive signs of impending haemorrhage. However, both the endoscopic and clinical criteria (Child) give a better evaluation of the risk of bleeding.
肝硬化的自然病程显示,三分之一的患者会发生食管静脉曲张出血。首次出血的死亡率为40%,70%的幸存者会在一年内再次出血。为了克服这一严重情况,人们尝试了以下几种预防性治疗方法:门腔分流术、β受体阻滞剂、内镜硬化治疗。医学文献表明这些治疗方法并无确凿益处。内镜硬化治疗似乎效果最佳。因此,为了取得更好的效果,我们建议更好地选择接受预防性硬化治疗的患者,同时改进能够预测出血的预后标准。食管镜检查能够检查一些即将出血的预测征象。然而,内镜标准和临床标准(Child分级)都能更好地评估出血风险。