D'haenen H A, Bossuyt A
Psychiatric Department, Academic Hospital, Free University of Brussels, Belgium.
Biol Psychiatry. 1994 Jan 15;35(2):128-32. doi: 10.1016/0006-3223(94)91202-5.
Psychobiological theories of mood disorders have been concerned mainly with noradrenaline and serotonin. There exists, however, a recent upsurge of interest in dopamine. We have used single photon emission computed tomography and 123I-iodobenzamide, a high-affinity ligand for D2 receptors, to study these receptors in depression. Subjects were 21 (unipolar) depressed inpatients and 11 normal controls. The mean basal ganglia/cerebellum uptake ratio was 1.94 (+/- 0.27) in the depressed patients versus 1.74 (+/- 0.17) in the controls. This difference was statistically significant (Mann-Whitney U test, p = 0.025). These data could indicate an increase of D2 receptor density in depression.
情绪障碍的心理生物学理论主要关注去甲肾上腺素和血清素。然而，最近人们对多巴胺的兴趣激增。我们使用单光子发射计算机断层扫描和123I-碘苯甲酰胺（一种D2受体的高亲和力配体）来研究抑郁症患者的这些受体。研究对象为21名（单相）抑郁住院患者和11名正常对照者。抑郁症患者基底节/小脑摄取率的平均值为1.94（±0.27），而对照组为1.74（±0.17）。这种差异具有统计学意义（曼-惠特尼U检验，p = 0.025）。这些数据可能表明抑郁症患者D2受体密度增加。
