Perry M E, Slípka J
Division of Anatomy and Cell Biology, UMDS, Guy's Hospital, University of London, U.K.
Funct Dev Morphol. 1993;3(3):165-8.
In this study of the human palatine tonsil we examined epithelial structures found always in the vicinity of the crypts and closely resembling thymic Hassall's corpuscles. We propose that in the reactive tonsillar lymphoid tissue these corpuscles form as a result of occlusion of fine microcrypts by the expanding lymphoid follicles during antigenic stimulation. The reticulated epithelial cells lining these microcrypts may then loose their polarisation, and gradually degenerate deep in the parenchyma, forming concentrically arranged parakeratotic pearls, rather than desquamate at the free epithelial surface. The structural similarities of the tonsillar and Hassall's corpuscles may be explained by endodermal embryological origin of the primordia of both organs, and by the specific degenerative properties of epithelia in the lymphoepithelial immune organs.
在这项对人类腭扁桃体的研究中，我们检查了总是在隐窝附近发现的上皮结构，这些结构与胸腺哈氏小体极为相似。我们提出，在反应性扁桃体淋巴组织中，这些小体是在抗原刺激期间，由于扩大的淋巴滤泡阻塞微小隐窝而形成的。衬于这些微小隐窝的网状上皮细胞随后可能会失去其极性，并在实质深部逐渐退化，形成同心排列的不全角化珠，而不是在游离上皮表面脱落。扁桃体小体与哈氏小体的结构相似性，可能是由于这两个器官原基的内胚层胚胎起源，以及淋巴上皮免疫器官中上皮细胞的特定退化特性所致。
