主要组织相容性复合体（MHC）对大鼠多瘤病毒BK致癌性和免疫原性的影响。
Influence of MHC on the oncogenicity and immunogenicity of polyoma virus BK in rats.
作者信息
Noss G, Verhagen W, Kunstyr I
机构信息
Institute of Virology, Medical School of Hannover, Germany.
出版信息
Zentralbl Bakteriol. 1994 Jan;280(3):392-7. doi: 10.1016/s0934-8840(11)80602-x.
The oncogenicity of the human papovavirus, type BK, was examined in the Lewis strain of inbred rats, possessing the recombinant alleles "a" and "u" on the MHC TR1 locus. It was found that only haplotypes containing "a" within the B/D locus but not within the A and the C locus of the RT1 region were associated with resistance to the oncogenic potential of BKV and with the capacity of animals to form BKV T antigen antibody. By contrast, the presence of "u" or "l" within the MHC B/D region was linked to the reverse phenotype characterized by sensitivity to the oncogenic effect of BKV and failure to yield T antibody response up to 6 months after inoculation with BK. These results present further evidence of the function as an immune control gene of the B/D region of the RT1 locus of rat MHC.
在MHC TR1位点具有重组等位基因“a”和“u”的近交系Lewis大鼠中，检测了BK型人乳头瘤病毒的致癌性。结果发现，只有在RT1区域的B/D位点而非A和C位点内含有“a”的单倍型，与对BKV致癌潜能的抗性以及动物形成BKV T抗原抗体的能力相关。相比之下，MHC B/D区域内存在“u”或“l”与相反的表型相关，其特征为对BKV的致癌作用敏感，并且在接种BK后长达6个月未能产生T抗体反应。这些结果进一步证明了大鼠MHC的RT1位点的B/D区域作为免疫控制基因的功能。
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