Corallini A, Barbanti-Brodano G, Bortoloni W, Nenci I, Cassai E, Tampieri M, Portolani M, Borgatti M
J Natl Cancer Inst. 1977 Nov;59(5):1561-4. doi: 10.1093/jnci/59.5.1561.
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified BK virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-fixation tests. A proportion of tumor-bearing animals had antibodies to BKV T-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendal virus-mediated fusion with Vero cells. A low, or lack of, oncogenic activity was displayed by BKV inoculated sc, ip, or iv.
将高滴度纯化的BK病毒（BKV）脑内接种到50只叙利亚金黄地鼠中的44只以及31只远交瑞士小鼠中的9只后，诱发产生了室管膜瘤。在免疫荧光和补体结合试验中，肿瘤含有一种与BKV特异性T抗体发生反应的T抗原。一部分荷瘤动物血清中含有针对BKV T抗原的抗体。通过仙台病毒介导的与非洲绿猴肾细胞融合，可从两个肿瘤细胞系中拯救出BKV。皮下、腹腔内或静脉内接种BKV显示出低致癌活性或无致癌活性。
