Miquel J, Herman M M, Benton E V, Welch G
Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Feb;29(2):101-24. doi: 10.1080/09553007614550131.
To investigate the effects of galactic heavy particles on nervous tissue, Drosophila melanogaster flies were exposed to 40A from the Super-HILAC accelerator at the Lawrence Berkeley Laboratory. The energy of the particles reaching the Drosophila neurons was 4-8 MeV/nucleon, and the fluence ranged from 6 X 10(4) to 8 X 10(7) particles/cm2. Thirty-five days after irrdiation at the higher fluences, extensive tissue fragmentation and cysts were found. At fluences as low as one hit/two cell bodies (about 5 X 10(6)) and one hit/90 cell bodies (about 9 X 10(4) particles/cm2 or 21 rad average dose) swelling of neuronal cytoplasm and focally fragmented membranes were noted; at fluences ranging from one hit/six to one hit/135 cell bodies, there was frequently a marked increase in glial lamellae around nerve-cell processes, which often had degenerative features. These findings support the view that single hits by heavy particles may injure nervous tissue.
为了研究银河系重粒子对神经组织的影响，将黑腹果蝇暴露于劳伦斯伯克利实验室的超级重离子线性加速器产生的40A粒子束下。到达果蝇神经元的粒子能量为4-8兆电子伏/核子，注量范围为6×10⁴至8×10⁷粒子/平方厘米。在较高注量照射35天后，发现广泛的组织破碎和囊肿。在低至一次击中/两个细胞体（约5×10⁶）和一次击中/90个细胞体（约9×10⁴粒子/平方厘米或平均剂量21拉德）的注量下，观察到神经元细胞质肿胀和膜局部破碎；在一次击中/六个至一次击中/135个细胞体的注量范围内，神经细胞突起周围的胶质板常常显著增加，且这些突起常有退行性特征。这些发现支持了重粒子单次击中可能损伤神经组织的观点。
