D'Amelio F E, Kraft L M, Benton E V, Miquel J
Acta Neuropathol. 1982;57(1):37-44. doi: 10.1007/BF00688875.
Fruit flies (Drosophila melanogaster) were exposed to high-LET krypton (84Kr) ions at low (4.2 rad) and high (1,584 rad) doses and killed to assess acute (36 h post-exposure) and late (35 days post-exposure) effects in the brain by means of electron microscopy. The main findings were: (a) glycogen granules appeared in the neuroglial compartment 36 h after exposure to either dose and were no longer present in flies killed 35 days later, (b) neuronal alterations (swelling and membrane disruption) were observed 35 days after exposure to both doses, (c) changes in the neuroglia (electron-dense masses of concentrically arranged membranous structures) were seen 35 days after exposure. The data are discussed in relation to previous research in the fruit fly using argon (40Ar) charged particles and to other radiation studies performed in the mammalian brain with the view of using the insect brain as a model for detailed study of radiation effects on neurons, neuroglia, and the neuron-neuroglia unit.
将果蝇（黑腹果蝇）暴露于低剂量（4.2拉德）和高剂量（1584拉德）的高传能线密度氪（84Kr）离子下，然后将其杀死，通过电子显微镜评估大脑中的急性（暴露后36小时）和晚期（暴露后35天）效应。主要发现如下：（a）在暴露于任一剂量36小时后，神经胶质区出现糖原颗粒，而在35天后处死的果蝇中不再存在；（b）在暴露于两种剂量35天后，观察到神经元改变（肿胀和膜破坏）；（c）在暴露35天后，可见神经胶质变化（同心排列的膜性结构的电子致密团块）。结合之前使用氩（40Ar）带电粒子对果蝇进行的研究以及在哺乳动物大脑中进行的其他辐射研究，对这些数据进行了讨论，目的是将昆虫大脑作为模型，详细研究辐射对神经元、神经胶质以及神经元 - 神经胶质单元的影响。
