宫颈发育异常和原位癌女性对致脑炎因子的细胞介导免疫（MMI试验）：血清的影响
Cell-mediated immunity to encephalitogenic factor (MMI test) in women with cervical dysplasia and carcinoma in situ: the effects of serum.
作者信息
Flavell D J, Singer A, Potter C W
出版信息
Br J Cancer. 1978 Sep;38(3):396-400. doi: 10.1038/bjc.1978.220.
Lymphocyte sensitivity to encephalitogenic factor (EF) was measured with the macrophage migration inhibition (MMI) test in 60 women with dysplasia or carcinoma in situ of the cervix, in 10 women with invasive cervical carcinoma, and in 20 women with a variety of benign gynaecological conditions. Significant migration inhibition with EF (P less than 0.01) was seen with lymphocytes taken from 7/13 (54%) women with mild and/or moderate dysplasia, from 22/47 (47%) women with severe dysplasia and/or carcinoma in situ, from 6/10 (60%) women with invasive cervical carcinoma and from 3/20 (15%) women with benign gynaecological conditions. Autologous serum was seen to abrogate EF-mediated migration inhibition in 3/4 sensitized women with mild and/or moderate dysplasia, in 5/7 sensitized women with severe dysplasia and/or csrcinoma in situ and in 2/3 sensitized women with invasive cervical carcinoma. Autologous serum from 2 sensitized women with benign gynaecological conditions did not abrogate the response of their lymphocytes to EF.
采用巨噬细胞游走抑制（MMI）试验，检测了60例宫颈发育异常或原位癌女性、10例浸润性宫颈癌女性以及20例患有各种良性妇科疾病女性的淋巴细胞对致脑炎因子（EF）的敏感性。在取自7/13（54%）轻度和/或中度发育异常女性、22/47（47%）重度发育异常和/或原位癌女性、6/10（60%）浸润性宫颈癌女性以及3/20（15%）良性妇科疾病女性的淋巴细胞中，观察到EF引起的显著游走抑制（P小于0.01）。在3/4轻度和/或中度发育异常的致敏女性、5/7重度发育异常和/或原位癌的致敏女性以及2/3浸润性宫颈癌的致敏女性中，自体血清可消除EF介导的游走抑制。来自2例患有良性妇科疾病的致敏女性的自体血清，并未消除其淋巴细胞对EF的反应。
Zotero 插件