Dickinson J P, Caspary E A, Field E J
Br J Cancer. 1973 Feb;27(2):99-105. doi: 10.1038/bjc.1973.13.
(1) The antigenic activity of basic protein extracts of a variety of human tissues towards sensitized lymphocytes from cancer patients has been studied using the macrophage electrophoretic migration method.(2) Basic protein prepared from human tumour tissue has antigenic properties which differ from basic protein prepared from normal tissues, from hyperplastic tissue and even tumour bearing host tissue.(3) Tumour type antigenic molecules are at least 10(4) times less numerous on normal cells than on tumour cells. If our reasoning is accepted then they are absent from normal cells, and thus restricted in vivo to malignant cells.(4) Hyperplastic tissues (gynaecomastia, etc.) do not contain cancer basic protein.(5) Human chronic lymphatic leukaemic leucocytes possess the same type of cancer antigenic activity as solid tumours. This antigenic activity is not shared by normal lymphocytes.
(1) 已使用巨噬细胞电泳迁移法研究了多种人体组织的碱性蛋白提取物对癌症患者致敏淋巴细胞的抗原活性。(2) 从人肿瘤组织制备的碱性蛋白具有与从正常组织、增生组织甚至荷瘤宿主组织制备的碱性蛋白不同的抗原特性。(3) 肿瘤型抗原分子在正常细胞上的数量比在肿瘤细胞上至少少10(4) 倍。如果我们的推理被接受，那么它们在正常细胞中不存在，因此在体内仅限于恶性细胞。(4) 增生组织（男性乳房发育症等）不含有癌碱性蛋白。(5) 人类慢性淋巴细胞白血病白细胞具有与实体瘤相同类型的癌症抗原活性。正常淋巴细胞不具有这种抗原活性。
