一种常见的肿瘤特异性抗原。I. 在体内对恶性肿瘤组织的局限性
A common tumour specific antigen. I. Restriction in vivo to malignant neoplastic tissue.
作者信息
Dickinson J P, Caspary E A, Field E J
出版信息
Br J Cancer. 1973 Feb;27(2):99-105. doi: 10.1038/bjc.1973.13.
Abstract
(1) The antigenic activity of basic protein extracts of a variety of human tissues towards sensitized lymphocytes from cancer patients has been studied using the macrophage electrophoretic migration method.(2) Basic protein prepared from human tumour tissue has antigenic properties which differ from basic protein prepared from normal tissues, from hyperplastic tissue and even tumour bearing host tissue.(3) Tumour type antigenic molecules are at least 10(4) times less numerous on normal cells than on tumour cells. If our reasoning is accepted then they are absent from normal cells, and thus restricted in vivo to malignant cells.(4) Hyperplastic tissues (gynaecomastia, etc.) do not contain cancer basic protein.(5) Human chronic lymphatic leukaemic leucocytes possess the same type of cancer antigenic activity as solid tumours. This antigenic activity is not shared by normal lymphocytes.
摘要
(1) 已使用巨噬细胞电泳迁移法研究了多种人体组织的碱性蛋白提取物对癌症患者致敏淋巴细胞的抗原活性。(2) 从人肿瘤组织制备的碱性蛋白具有与从正常组织、增生组织甚至荷瘤宿主组织制备的碱性蛋白不同的抗原特性。(3) 肿瘤型抗原分子在正常细胞上的数量比在肿瘤细胞上至少少10(4) 倍。如果我们的推理被接受，那么它们在正常细胞中不存在，因此在体内仅限于恶性细胞。(4) 增生组织（男性乳房发育症等）不含有癌碱性蛋白。(5) 人类慢性淋巴细胞白血病白细胞具有与实体瘤相同类型的癌症抗原活性。正常淋巴细胞不具有这种抗原活性。
相似文献
1
A common tumour specific antigen. I. Restriction in vivo to malignant neoplastic tissue.一种常见的肿瘤特异性抗原。I. 在体内对恶性肿瘤组织的局限性
Br J Cancer. 1973 Feb;27(2):99-105. doi: 10.1038/bjc.1973.13.
2
Rapid development of a cancer-like antigen in normal tissue in vitro.体外正常组织中癌样抗原的快速形成
Br J Cancer. 1973 Jun;27(6):427-33. doi: 10.1038/bjc.1973.53.
3
Lymphocyte sensitization to basic protein of brain in malignant neoplasia: experiments with serotonin and related compounds.恶性肿瘤中淋巴细胞对脑碱性蛋白的致敏作用：血清素及相关化合物的实验
Nature. 1971 Sep 24;233(5317):284-6. doi: 10.1038/233284a0.
4
The macrophage electrophoretic mobility test for malignancy.巨噬细胞恶性肿瘤电泳迁移率试验
Ann Clin Lab Sci. 1974 Mar-Apr;4(2):121-4.
5
Differences of the in vitro reactivity of lymphocytes from normal and persistently lymphocytotic cows to enzootic bovine leukosis tumour membrane extracts as detected with the macrophage-electrophoretic mobility test.用巨噬细胞电泳迁移率试验检测正常和持续性淋巴细胞增多奶牛的淋巴细胞对地方流行性牛白血病肿瘤膜提取物的体外反应性差异。
Acta Biol Med Ger. 1982;41(7-8):705-13.
6
The modulation of tumour-versus-host response in lung, colon, and breast cancer patients: implications for adjuvant immunochemotherapy.肺癌、结肠癌和乳腺癌患者肿瘤与宿主反应的调节：对辅助免疫化疗的意义。
Aust N Z J Surg. 1977 Oct;47(5):642-7. doi: 10.1111/j.1445-2197.1977.tb06596.x.
7
Macrophage electrophoretic mobility (MEM) test in cancer: a critical evaluation.癌症中的巨噬细胞电泳迁移率（MEM）测试：一项批判性评估。
Br J Cancer Suppl. 1973 Aug;1:208-14.
8
Sensitization to tumour-associated antigens in human breast carcinoma.人类乳腺癌中对肿瘤相关抗原的致敏作用。
Int J Cancer. 1974 Jul 15;14(1):19-25. doi: 10.1002/ijc.2910140103.
9
[Immunologic localization of primary tumors].[原发性肿瘤的免疫定位]
Chirurg. 1982 Apr;53(4):258-62.
10
Technical aspects of the macrophage electrophoretic mobility (MEM) test for malignant disease.用于恶性疾病的巨噬细胞电泳迁移率（MEM）检测的技术方面。
Br J Cancer Suppl. 1973 Aug;1:229-36.
引用本文的文献
1
Colorectal Cancer Immunotherapy: Options and Strategies.结直肠癌免疫治疗：选择与策略。
Front Immunol. 2020 Sep 18;11:1624. doi: 10.3389/fimmu.2020.01624. eCollection 2020.
2
Cellular immunity to encephalitogenic peptide in tumour-bearing mice.荷瘤小鼠对致脑炎肽的细胞免疫。
Br J Cancer. 1982 May;45(5):754-61. doi: 10.1038/bjc.1982.117.
3
Cell electrophoresis for diagnostic purposes. I. Diagnostic value of the electrophoretic mobility test (EMT) for the detection of gynaecological malignancies.用于诊断目的的细胞电泳。I. 电泳迁移率测试（EMT）在检测妇科恶性肿瘤中的诊断价值。
Br J Cancer. 1981 May;43(5):588-97. doi: 10.1038/bjc.1981.88.
4
A common tumour specific antigen. II. Further characterization of the whole antigen and of a cross-reacting antigen of normal tissues.一种常见的肿瘤特异性抗原。II. 全抗原及正常组织交叉反应抗原的进一步特性分析
Br J Cancer. 1974 Jun;29(6):425-32. doi: 10.1038/bjc.1974.94.
5
Remarks to the paper of H. Meyer-Rienecker, H.-L. Jenssen, H. Köhler, J. Günther und H. J. Gundlach: Utilization and significance of the macrophages-electrophoresis-mobility (MEM)-test in neurologic diseases.对H. 迈耶 - 里内克、H.-L. 延森、H. 克勒、J. 京特和H. J. 贡德拉克论文的评论：巨噬细胞电泳迁移率（MEM）试验在神经系统疾病中的应用及意义
Klin Wochenschr. 1974 Nov 15;52(22):1091. doi: 10.1007/BF01468999.
6
7
Antigen cross-reactivity in the macrophage electrophoretic mobility test. A study using cellular affinity chromatography.巨噬细胞电泳迁移率试验中的抗原交叉反应性。一项使用细胞亲和层析的研究。
Clin Exp Immunol. 1974 May;17(1):103-11.
8
Measurement by leukocyte adherence inhibition of autosensitization of cancer patients to myelin basic protein.通过白细胞黏附抑制法检测癌症患者对髓鞘碱性蛋白的自身致敏作用。
Jpn J Cancer Res. 1988 Apr;79(4):529-37. doi: 10.1111/j.1349-7006.1988.tb01623.x.
9
[Carcinofetal antigens. III. Further carcinofetal antigens (author's transl)].癌胚抗原。III. 更多的癌胚抗原（作者译）
Klin Wochenschr. 1975 May 1;53(9):403-17. doi: 10.1007/BF01493365.
10
Macrophage electrophoretic mobility (MEM) test in malignant gynaecological diseases.妇科恶性疾病中的巨噬细胞电泳迁移率（MEM）检测
Arch Gynakol. 1976 Mar 5;220(3):191-8. doi: 10.1007/BF00667747.
本文引用的文献
1
SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.从人血中分离活淋巴细胞
Lancet. 1964 Feb 29;1(7331):468-9. doi: 10.1016/s0140-6736(64)90799-8.
2
Multiple forms of esterases from human erythrocytes.人红细胞酯酶的多种形式。
Proc Soc Exp Biol Med. 1961 Nov;108:364-6. doi: 10.3181/00379727-108-26939.
3
Antigenicity of pooled human malignant and normal tissues by cyto-immunological technique; presence of an insoluble, heat-labile tumor antigen.采用细胞免疫学技术检测人恶性组织和正常组织混合样本的抗原性；存在一种不溶性、热不稳定的肿瘤抗原。
Int Arch Allergy Appl Immunol. 1957;10(3):153-84.
4
Systematic antigenic change in human carcinoma tissues by hemagglutination techniques.采用血凝技术对人癌组织进行系统性抗原变化研究。
Int Arch Allergy Appl Immunol. 1969;36(1):191-203. doi: 10.1159/000230741.
5
In vitro methods in cell-mediated immunity in man.人体细胞介导免疫的体外方法。
N Engl J Med. 1971 May 27;284(21):1212-3. doi: 10.1056/NEJM197105272842111.
6
Demonstration of sensitized lymphocytes in blood.血液中致敏淋巴细胞的检测
J Clin Pathol. 1971 Mar;24(2):179-81. doi: 10.1136/jcp.24.2.179.
7
Recognition of leukaemia cells as foreign before and after autoimmunization.自身免疫前后对白血病细胞作为外来物的识别。
Br Med J. 1971 Feb 27;1(5747):486-9. doi: 10.1136/bmj.1.5747.486.
8
Immune response to urinary bladder tumours in man.人类对膀胱肿瘤的免疫反应。
Int J Cancer. 1970 Jan 15;5(1):39-46. doi: 10.1002/ijc.2910050106.
9
Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.通过氚标记胸腺嘧啶核苷摄取法体外测定淋巴细胞转化。I. 淋巴细胞培养技术。
Int Arch Allergy Appl Immunol. 1970;37(5):506-31. doi: 10.1159/000230240.
10
Identification of a tumour antigen.肿瘤抗原的鉴定。
Biochem J. 1972 Feb;126(3):5P-6P. doi: 10.1042/bj1260005p.
Zotero 插件