癌症基础蛋白的化学性质。
The chemical nature of cancer basic protein.
作者信息
Dickinson J P, Caspary E A
出版信息
Br J Cancer Suppl. 1973 Aug;1:224-8.
Abstract
Experimental evidence is put forward supporting the notion of a cell sensitizing antigen present in all malignant tumours and its restriction to malignant tissue pointed out. In addition to this common tumour specific antigen an antigen apparently present in all tissues, but distinguished from tumour antigen on the basis of its relative activity, is described. Both of these antigens are shown to be, like the encephalitogen of brain, basic proteins of molecular weight 16-18,000 daltons, having proteolipid properties, present on the external surface of the plasma membrane and carrying the cell sensitizing property in a small fragment of the whole protein.
摘要
提出了实验证据，支持所有恶性肿瘤中存在细胞致敏抗原这一概念，并指出其对恶性组织的局限性。除了这种常见的肿瘤特异性抗原外，还描述了一种显然存在于所有组织中，但根据其相对活性与肿瘤抗原不同的抗原。这两种抗原都被证明，与脑的脑髓炎原一样，是分子量为16 - 18,000道尔顿的碱性蛋白质，具有蛋白脂质特性，存在于质膜外表面，并在整个蛋白质的一小部分中具有细胞致敏特性。
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本文引用的文献
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AN ENCEPHALITOGENIC PROTEIN OF HUMAN ORIGIN: SOME CHEMICAL AND BIOLOGICAL PROPERTIES.一种人类源致脑炎蛋白：一些化学和生物学特性
Ann N Y Acad Sci. 1965 Mar 31;122:182-98. doi: 10.1111/j.1749-6632.1965.tb20202.x.
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An acrylamide gel soluble in scintillation fluids: its application to electrophoresis at neutral and low pH.一种可溶于闪烁液的丙烯酰胺凝胶：其在中性和低pH值下的电泳应用
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Nature. 1970 Sep 12;227(5263):1133-4. doi: 10.1038/2271133a0.
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