Goroshinskaia I A, Nemashkalova L A, Khodakova A A, Sorokina I V
Fiziol Zh Im I M Sechenova. 1993 Oct;79(10):67-73.
The effects of 3 and 10-day intermittent hypoxia corresponding to the altitude 5000 m, during 4 hrs a day, were studied. Daily administration of pyrazidol exerted a normalising effect on the plasma total peroxidase activity, extra erythrocyte hemoglobin concentration and adrenal ascorbic acid content. Unprotected rats developed a 2-fold reduction of the body mass under the 10-day hypoxia. Administration of pyrazidol normalises catecholamines content in the hypothalamus and brain cortex in the 3-day hypoxia, prevents a monoamine content decrease in the hypothalamus and adrenals in the 10-day hypoxia, promotes a serotonin increase in the brain areas. Adrenal norepinephrine content was twice as large in the protected animals than in unprotected those. An adaptogenic role of pyrazidol under conditions of an intermittent hypoxia is discussed.
研究了每天4小时、相当于海拔5000米的3天和10天间歇性缺氧的影响。每天给予吡嗪醇对血浆总过氧化物酶活性、红细胞外血红蛋白浓度和肾上腺抗坏血酸含量具有正常化作用。未受保护的大鼠在10天缺氧条件下体重减轻了一半。给予吡嗪醇可使3天缺氧时下丘脑和大脑皮层中的儿茶酚胺含量正常化，防止10天缺氧时下丘脑和肾上腺中的单胺含量降低，促进脑区中血清素增加。受保护动物的肾上腺去甲肾上腺素含量是未受保护动物的两倍。讨论了吡嗪醇在间歇性缺氧条件下的适应原作用。
