Goroshinskaia I A, Neskubina I V
Rostov Research Oncology Institute, Russia.
Vopr Med Khim. 1998 May-Jun;44(3):248-55.
The effects of single acute hypoxia (9000 m above the sea level, 3h) and intermittent hypoxia (5000 m 4 h daily during 3 and 10 days) were studied. Acute hypoxia was characterized by the increase in the content of brain serotonin, dopamine and norepinephrine accompanied by a decrease of deaminated product. The increase of monoamine contents in hypothalamus and adrenals during initial stage caused to considerable extent by their deamination and the monoamine decrease under 10-day hypoxia were typical for intermittent hypoxia. The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state.
研究了单次急性缺氧（海拔9000米，3小时）和间歇性缺氧（海拔5000米，每天4小时，持续3天和10天）的影响。急性缺氧的特征是脑内5-羟色胺、多巴胺和去甲肾上腺素含量增加，同时脱氨基产物减少。下丘脑和肾上腺在初始阶段单胺含量的增加在很大程度上是由它们的脱氨基作用引起的，而10天缺氧期间单胺含量的降低是间歇性缺氧的典型特征。给予单胺氧化酶A抑制剂吡唑醇可促进脑内5-羟色胺含量增加，使脑内儿茶酚胺含量正常化，并对动物状态产生积极影响。
