[缺氧时细胞膜酶的状态及吡唑醇的保护作用]

[Status of cell membrane enzymes in hypoxia and the protective effect of pyrazidole].

作者信息

Goroshinskaia I A, Mogil'nitskaia L V, Nemashkalova L A, Khodakova A A

出版信息

Biokhimiia. 1993 Jan;58(1):62-9.

Abstract

The influence of hypobaric hypoxia simulating the altitude of 9000 m above the sea level during 3 hours on the stability of erythrocyte, lysosomal, and mitochondrial membranes, has been studied. The increase in extra erythrocyte hemoglobin and free iron concentrations and the total peroxidase activity in blood plasma testify to increased permeability of the erythrocyte membrane. An increase in the free activity of acid peptide hydrolases in the soluble fraction and their activity decrease in the lysosomal membrane. The mitochondrial monoamine oxidase activity in the soluble fraction of the brain is suggestive of structural damages to the mitochondrial membrane. Preliminary administration of pyrasidol prior to hypoxia has a stabilizing effect on all types of membrane structures.

摘要

研究了模拟海拔9000米的低压低氧环境持续3小时对红细胞、溶酶体和线粒体膜稳定性的影响。红细胞外血红蛋白和游离铁浓度的增加以及血浆中总过氧化物酶活性的升高证明红细胞膜通透性增加。可溶性部分酸性肽水解酶的游离活性增加，而溶酶体膜中的活性降低。脑可溶性部分的线粒体单胺氧化酶活性表明线粒体膜存在结构损伤。缺氧前预先给予匹拉西多对所有类型的膜结构具有稳定作用。